CO_(2) combining power and outcomes in patients with acute ischaemic stroke or transient ischaemic attack

查看全文 作　　者：Anxin [1,2]Wang;Xue [3,4]Tian;Hongqiu [1,2]Gu;Yingting [3,4]Zuo;Xia [1,2]Meng;Wei [1,2]Lv;Hao [1,2]Li;Yongjun [1,2]Wang

机构地区：[1]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;[2]Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;[3]Department of Epidemiology and Health Statistics,School of Public Health,Capital Medical University,Beijing,China;[4]Beijing Municipal Key Laboratory of Clinical Epidemiology,Beijing,China

出　　处：《Stroke & Vascular Neurology》索引2021年第6卷第2期,共8页

基　　金：supported by the Young Elite Scientists Sponsorship Program by CAST(2018QNRC001);the Beijing Municipal Administration of Hospitals Incubating Program(PX2020021);the Beijing Municipal Science&Technology Commission(D171100003017002);the National Science and Technology Major Project(2017ZX09304018). 摘　　要：Background and purpose The clinical significance of carbon dioxide combining power(CO_(2) CP)in ischaemic cerebrovascular disease is not well established,and the role of CO_(2) CP in the prognosis of acute ischaemic stroke(AIS)or transient ischaemic attack(TIA)has not been reported.The objective of the study was to investigate the associations between CO2CP and clinical outcomes in patients with AIS or TIA.Methods Data were derived from the China National Stroke Registry III.Patients were classified into five groups by quintiles of CO_(2) CP levels and three groups according to the normal range of CO_(2)CP(23-29 mmol/L).Multivariable Cox and logistic regressions were adopted to explore the associations of CO_(2) CP levels with all-cause death and poor functional outcomes(modified Rankin Scale(mRS)3-6/2-6)at 3 months and 1 year.Results Among 9531 patients included in the study,the median(IQR)CO_(2) CP was 24.9(23.0-27.0)mmol/L.After adjustment for potential confounders,patients in the first CO_(2) CP quintile(21.1-23.3 mmol/L)had higher risk of all-cause death and poor functional outcomes(mRS score of 3-6/2-6)(HR or OR with 95% CI 2.37(1.32 to 4.25),1.49(1.20 to 1.83)and 1.21(1.03 to 1.42),respectively)compared with those in the fourth quintile.Similar results were found for outcomes at 1 year.Furthermore,all associations were also significant when CO_(2) CP was<23 mmol/L compared with CO_(2) CP of 23-29 mmol/L.Conclusions Decreased CO_(2) CP was associated with high risk of all-cause death and poor functional outcomes in patients with AIS or TIA. 关键词：PATIENTS ISCHAEMIC ACUTE

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CO_(2) combining power and outcomes in patients with acute ischaemic stroke or transient ischaemic attack

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