Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy

查看全文 作　　者：Ke [1]Rui;Xiang [2]Lin;Jie [3]Tian;Xiaohui [2]Wang;Lingyun [4]Sun;Xiaoping [5]Hong;Dongzhou [5]Liu;Shengjun [3]Wang;Liwei [2]Lu

机构地区：[1]Department of Laboratory Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang,China;[2]Department of Pathology and Shenzhen Institute of Research and Innovation,The University of Hong Kong,Hong Kong,China;[3]Department of Laboratory Medicine,and Jiangsu Key Laboratory of Laboratory Medicine,Jiangsu University Medical School,Zhenjiang,China;[4]Department of Rheumatology and Immunology,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;[5]Department of Rheumatology and Immunology,2nd Clinical Medical College of Jinan University,Shenzhen People's Hospital,Shenzhen,China

出　　处：《Cellular & Molecular Immunology》索引2018年第15卷第1期,共3页

基　　金：This study was supported by grants from the Natural Science Foundation of Jiangsu(BK20170563);National Natural Science Foundation of China(No.81373195);National Basic Research Program of China(2014CB541904);and Natural Science Foundation of Jiangsu(BK20150533). 摘　　要：Extensive studies have demonstrated that mesenchymal stem cells(MSCs)are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types,including adipocytes,osteoblasts,chondrocytes,myocytes and neuronal cells.1 MSCs are found in numerous organs and tissues,including bone marrow,heart,lung,muscle,peripheral blood,adipose tissue,cartilage,synovium,dental pulp,tonsil,umbilical cord,placenta,thymus and olfactory mucosa.1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities,which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis,including rheumatic diseases and graft-versus-host diseases.2,3 Here,we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells. 关键词：ORGANS LUNG GRAFT

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Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy

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