Current advances in using neurotrophic factors to treat neurodegenerative disorders

查看全文 作　　者：April M [1]Weissmiller;Chengbiao [1,2]Wu

机构地区：[1]Department of Neurosciences,University of California San Diego,School of Medicine,La Jolla,CA 92093-0649,USA;[2]Department of Neurosciences,University of California San Diego,George Palade Labs(GPL),Room 337 MC-0649,9500 Gilman Drive,La Jolla,CA 92093,USA

出　　处：《Translational Neurodegeneration》索引2012年第1卷第1期,共9页

基　　金：This work was funded by NIH Neuroplasticity of Aging Predoctoral Training Grant to AW,UCSD NIH ADRC Pilot Grant,LLHF and DSRTF to CW. 摘　　要：Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system.Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders.However,significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena.This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments. 关键词：NEUROTROPHIN Neurotrophic factor BDNF NGF Gene delivery MIMETICS

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Current advances in using neurotrophic factors to treat neurodegenerative disorders

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