Flagellin: a unique microbe-associated molecular pattern and a multi-faceted immunomodulator

查看全文 作　　者：Maohua [1]Zhong;Huimin [1]Yan;Yaoming [1]Li

机构地区：[1]Mucosal Immunity Research Group,State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China

出　　处：《Cellular & Molecular Immunology》索引2017年第14卷第10期,共3页

摘　　要：Mammals peacefully co-exist with vast numbers of different bacteria most of the time.Whether pathogenic,nonpathogenic or commensal to a mammalian host,bacteria produce microbeassociated molecular patterns(MAMPs)or pathogen-associated molecular patterns(PAMPs)that are recognized by multiple classes of germline-encoded pattern-recognition receptors(PRRs).Flagellin,a major structural protein of bacterial flagella,is composed of four domains(D0,D1,D2 and D3),of which the D0 and D1 domains are the most highly conserved. 关键词：PATTERN peace MOLECULAR

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Flagellin: a unique microbe-associated molecular pattern and a multi-faceted immunomodulator

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