Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection

查看全文 作　　者：Yuan [1,2]Liu;Jian [1]Zheng;Yinping [1]Liu;Liyan [1]Wen;Lei [3,4]Huang;Zheng [1]Xiang;Kwok-Tai [1]Lam;Aizhen [1]Lv;Huawei [1,5]Mao;Yu-Lung [1]Lau;Wenwei [1]Tu

机构地区：[1]Department of Pediatrics and Adolescent Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China;[2]Medical Genetic Center,Guangdong Women and Children Hospital,Guangzhou 511400,China;[3]Department of Radiology,Georgia Regents University,Augusta,GA 30912,USA;[4]GRU Cancer Center,Georgia Regents University,Augusta,GA 30912,USA;[5]Department of Pediatrics,The University of Hong Kong—Shenzhen Hospital,Shenzhen 518053,China

出　　处：《Cellular & Molecular Immunology》索引2018年第15卷第9期,共11页

基　　金：This work was supported in part by Research Fund for the Control of Infectious Diseases,Hong Kong SAR government(11100742);General Research Fund,Research Grants Council of Hong Kong(HKU 780113M,17121214,17115015);Area of Excellence program on Influenza(AoE/M-12/06);Theme-based Research Scheme from the Research Grants Council of the Hong Kong SAR,China(Project No.T11-705/14N);HKU Small Project Funding(201309176043)。 摘　　要：Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. 关键词：CTL INFLUENZA NK cell

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Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection

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