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Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment

查看全文 作　　者：Qiang [1]Huang;Mei [1]Huang;Futao [1]Meng;Rui [2]Sun 高影响力作者 机构地区：[1]Department of General Surgery,The First Affiliated Hospital of University of Science and Technology of China,Hefei,China;[2]Institute of Immunology,School of Life Science and Medical Center,University of Science and Technology of China,Hefei,China高影响力机构 出　　处：《Cellular & Molecular Immunology》索引2019年第16卷第1期,共3页高影响力期刊 基　　金：This study was supported by the National Natural Science Foundation of China (81501354). 摘　　要：Pancreatic ductal adenocarcinoma(PDAC)is one the most malignant cancers and has been shown to have increasing morbidity and mortality in recent years.1 Since PDAC is always diagnosed at an advanced stage,only a few patients are suitable for surgical resection.Most patients who receive chemotherapy or radiotherapy targeting pancreatic cancer do not significantly benefit from these treatments.2 Accumulating evidence has indicated that the microenvironment composed of pancreatic cancer cells and other cell types is critical in regulating tumor progression,which could serve as a therapeutic target for PDAC. 关 键 词：CANCER CHEMOTHERAPY MORTALITY
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