Innate lymphoid cell memory

查看全文 作　　者：Xianwei [1,2]Wang;Hui [1,2]Peng;Zhigang [1,2]Tian

机构地区：[1]Division of Molecular Medicine,Hefei National Laboratory for Physical Sciences at Microscale,The CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Life Sciences,University of Science and Technology of China,Hefei 230027 Anhui,China;[2]Institute of Immunology,University of Science and Technology of China,Hefei 230027 Anhui,China

出　　处：《Cellular & Molecular Immunology》索引2019年第16卷第5期,共7页

基　　金：supported by the Natural Science Foundation of China(#81788101,81761128013,81571522,91642105,91542114,and 91542000). 摘　　要：Innate lymphoid cells(ILCs),including natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells,comprise the first line of innate immune defense against pathogens and tumors.Over the past decade,accumulating evidence has demonstrated immunological memory in ILC subsets:for example,NK cells recall haptens,viruses,and cytokines;ILC1s recall haptens;and ILC2s recall cytokines.Although the development and functions of ILCs mirror those of T-cell subsets,ILC and T-cell memory exhibit both common characteristics and specific properties.Encouragingly,ILC memory has been found to confer benefits in long-term tumor control and vaccination,providing insight for novel memory ILC-based tumor immunotherapy and vaccine-development strategies.In this review,we discuss the evidence supporting ILC memory and present a comprehensive framework of the ILC memory system. 关键词：LYMPHOID VACCINE KILLER

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Innate lymphoid cell memory

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