Chemical Constituents from the Whole Plant of Cuscuta reflexa

查看全文 作　　者：Tin Thu Thu [1,3]Aung;Meng-Yuan [1]Xia;Pyae Phyo [1,3]Hein;Rong [1]Tang;Dong-Dong [1,4]Zhang;Jun [1,4]Yang;Xue-Fei [1,4]Yang;Dong-Bao [2]Hu;Yue-Hu [1,4]Wang 机构地区：[1]Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China;[2]School of Chemical Biology and Environment,Yuxi Normal University,Yuxi 653100,People’s Republic of China;[3]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China;[4]Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences,Yezin,Nay Pyi Taw 05282,Myanmar 出　　处：《Natural Products and Bioprospecting》索引2020年第10卷第5期,共8页 基　　金：supported by the Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences(Grant Nos.2015CASEABRIRG001 and Y4ZK111B01);the International Partnership Program of Chinese Academy of Sciences(Grant No.153631KYSB20160004);the National Natural Science Foundation of China(31960480);the Joint Special Project of Local Undergraduate Universities in Yunnan Province,China(Grant No.2018FH001-024);the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program of Ministry of Science and Technology of the People’s Republic of China(Grant No.2019QZKK0502). 摘　　要：Two new 2H-pyran-2-one glucosides,cuscutarosides A(1)and B(2),and one new steroidal glucoside,7β-methoxy-β-sitosterol 3-O-β-glucopyranoside(3),together with 12 known compounds(4-15)were isolated from the whole plant of Cuscuta reflexa(Convolvulaceae)collected from Myanmar.The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis.The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase(PPL),and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin,platelet-activating factor(PAF),arachidonate(AA),or collagen.7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside(3)showed weak PPL inhibitory activity.Cuscutaroside A(1),its acetylated derivative(1a),and scrophenoside B(8)showed weak inhibitory activity against rabbit platelet aggregation induced by collagen.Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. 关 键 词：Cuscuta reflexa Porcine pancreatic lipase Platelet aggregation 2H-pyran-2-one glucosides Steroidal glucosides