维普中文期刊产品整合服务

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

查看全文 作　　者：Hong [1]Gao;Ying [1,2]Zhuo;Elizabeth [1]Ashforth;Lixin [1]Zhang 高影响力作者 机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology&Immunology,Institute of Microbiology,Chinese Academy of Sciences(CAS),Beijing 100101,China;[2]Graduate University of Chinese Academy of Sciences,Beijing 100049,China高影响力机构 出　　处：《Protein & Cell》索引2010年第1卷第7期,共6页高影响力期刊 基　　金：supported in part by grants from the National Programs for High Technology Research and Development Program(863 Program)(Grant Nos.2006AA09Z402,2007AA09Z443);the National Basic Research Program of China(973 Program)(Grant No.2004CB719601);National Natural Science Foundation of China(Grant Nos.30560001,30600001,30700015);National Key Technology R&D Program(2007BAI26B02);the National Science&Technology Pillar Program(No.200703295000-02);Important National Science&Technology Specific Projects(Nos.2008ZX09401-005,2009ZX09302-004);Science and Technology Planning Project of Guangdong Province,China(No.2006A50103001);Key Project of International Cooperation(2007DFB31620)。 摘　　要：Synthetic biology aims to design and build new biological systems with desirable properties,providing the foundation for the biosynthesis of secondary metabolites.The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology.However,there are advantages of using a deleted host,and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genomereduced microbes.This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites. 关 键 词：synthetic biology reduced-genome secondary metabolite
相关文献

参考文献(37)

引证文献(5)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费