NF-κB and STAT3 signaling pathways collaboratively link infl ammation to cancer

查看全文 作　　者：Yihui [1]Fan;Renfang [2]Mao;Jianhua [1]Yang

机构地区：[1]Texas Children's Cancer Center,Department of Pediatrics,Dan L.Duncan Cancer Center,Baylor College of Medicine,Houston,TX 77030,USA;[2]The Methodist Hospital Research Institute and the Departments of Radiology,the Methodist Hospital,Houston,TX 77030,USA

出　　处：《Protein & Cell》索引2013年第4卷第3期,共10页

基　　金：supported by the NIH/NINDS grant 1R01NS072420-01. 摘　　要：Although links between cancer and inflammation were fi rstly proposed in the nineteenth century,the molecular mechanism has not yet been clearly understood.Epidemiological studies have identified chronic infections and infl ammation as major risk factors for various types of cancer.NF-κB transcription factors and the signaling pathways are central coordinators in innate and adaptive immune responses.STAT3 regulates the expression of a variety of genes in response to cellular stimuli,and thus plays a key role in cell growth and apoptosis.Recently,roles of NF-κB and STAT3 in colon,gastric and liver cancers have been extensively investigated.The activation and interaction between STAT3 and NF-κB play vital roles in control of the communication between cancer cells and infl ammatory cells.NF-κB and STAT3 are two major factors controlling the ability of pre-neoplastic and malignant cells to resist apoptosis-based tumor-surveillance and regulating tumor angiogenesis and invasiveness.Understanding the molecular mechanisms of NF-κB and STAT3 cooperation in cancer will offer opportunities for the design of new chemo-preventive and chemotherapeutic approaches. 关键词：infl ammation TUMORIGENESIS NF-ΚB STAT3

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NF-κB and STAT3 signaling pathways collaboratively link infl ammation to cancer

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