Testosterone,cardiomyopathies,and heart failure:a narrative review

查看全文 作　　者：Rodica [1]Diaconu;Ionuţ [1]Donoiu;Oana [1]Mirea;Tudor Adrian [2]Bălşeanu

机构地区：[1]Department of Cardiology,University of Medicine and Pharmacy,Craiova 200349,Romania;[2]Department of Physiology,University of Medicine and Pharmacy,Craiova 200349,Romania

出　　处：《Asian Journal of Andrology》索引2021年第23卷第4期,共9页

摘　　要：Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure. 关键词：ANDROGENS CARDIOMYOCYTES heart disease MYOCARDIAL prognosis

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Testosterone,cardiomyopathies,and heart failure:a narrative review

参考文献(141)

引证文献(3)

耦合文献(15)

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