Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

查看全文 作　　者：Jie [1]Zhang;Chen [3]Tian;Fang [3]Lv;Jianfei [3]Wang;Wenbo [3]Han;Jun [1]Nie;Ling [1]Dai;Weiheng [1]Hu;Xiaoling [1]Chen;Xiangjuan [1]Ma;Guangming [1]Tian;Di [1]Wu;Sen [1]Han;Yang [1]Wang;Jieran [1]Long;Ziran [1]Zhang;Jian [1]Fang;Henghui [2,3]Zhang

机构地区：[1]Department of Thoracic Oncology II,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,P.R.China;[2]Institute of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100011,P.R.China;[3]Beijing Genecast Biotechnology Co.,Beijing 100191,P.R.China

出　　处：《Cancer Communications》索引2019年第39卷第1期,共5页

基　　金：This study was sponsored by the Beijing Genecast Biotechnology Co.,Beijing,China. 摘　　要：Dear Editor,Lung cancer is the predominant cause of cancer-related death worldwide[1].Non-small cell lung cancer accounts for 80%-85%and small cell lung cancer(SCLC)accounts for 15%-20%of all lung cancer cases[2].Patients with SCLC,a highly aggressive and poorly differentiated malignancy,have an alarming average 5-year overall sur-vival rate of less than 10%[3].Most patients with SCLC already show clinically detectable metastases at diag-nosis and have extremely poor prognoses,even when treated with multimodality therapy[4].Before the addi-tion of atezolizumab to chemotherapy became the first-line treatment of extensive-stage SCLC,chemotherapy is the primary treatment of SCLC[5]. 关键词：CHEMOTHERAPY LUNG PATIENTS

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Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

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