New insights from the widening homogeneity perspective to target intratumor heterogeneity

查看全文 作　　者：Mengying [1]Tong;Ziqian [1]Deng;Xiaolong [1]Zhang;Bin [2]He;Mengying [1]Yang;Wei [1]Cheng;Quentin [1,2,3]Liu

机构地区：[1]Institute of Cancer Stem Cell,Cancer Center,Dalian Medical University,Dalian 116044,Liaoning,P.R.China;[2]State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou 510630,Guangdong,P.R.China;[3]Department of Hematology,The Third Affiliated Hospital,Sun Yat-sen Univerisity,Guangzhou 510630,Guangdong,P.R.China

出　　处：《Cancer Communications》索引2018年第38卷第1期,共7页

基　　金：supported by Innovative Research Team in University of Ministry of Education of China(No.IRT_17R15);National Natural Science Foundation of China(No.81630005 to QL,No.81573025 to QL);Dalian high-level talent innovation program(2016RD12 to QL);International scientific and technological cooperation of Dalian(2015F11GH095 to QL). 摘　　要：Precision medicine has shed new light on the treatment of heterogeneous cancer patients.However,intratumor heterogeneity strongly constrains the clinical benefit of precision medicine.Thus,rethinking therapeutic strategies from a different facet within the precision medicine framework will not only diversify clinical interventions,but also provide an avenue for precision medicine.Here,we explore the current approaches for targeting intratumor hetero-geneity and their limitations.Furthermore,we propose a theoretical strategy with a“homogenization”feature based on iatrogenic evolutionary selection to target intratumor heterogeneity. 关键词：Acquired drug resistance HOMOGENIZATION Intratumor heterogeneity Plasticity Precision medicine

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New insights from the widening homogeneity perspective to target intratumor heterogeneity

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