The noncanonical role of the protease cathepsin D as a cofilin phosphatase

查看全文 作　　者：Yi-Jun [1,2]Liu;Ting [1,2]Zhang;Sicong [3]Chen;Daxiao [1,2]Cheng;Cunjin [2]Wu;Xingyue [1,2]Wang;Duo [2]Duan;Liya [1,2]Zhu;Huifang [1,2]Lou;Zhefeng [2]Gong;Xiao-Dong [2,4]Wang;Margaret [5]S.Ho;Shumin [1,2]Duan

机构地区：[1]Department of Neurobiology and Department of Neurology of Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310009,China;[2]Research Units for Emotion and Emotion Disorders,NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain-Machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou,Zhejiang 310058,China;[3]Clinical Research Center,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310009,China;[4]Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310016,China;[5]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Cell Research》索引2021年第31卷第7期,共13页

基　　金：supported by National Key Research and Development Program of China(2016YFA0501000);National Natural Science Foundation of China(81821091,31501128,31490592,31871039,81971260,81761138044,81527901,81801330,and 91832000);Key Research and Development Program of Zhejiang Province(2020C03009);Science and Technology Planning Project of Guangdong Province(2018B030331001);Key Realm R&D Program of Guangdong Province(2019B030335001);Chinese Ministry of Education Project 111 Program(B13026). 摘　　要：Cathepsin D(cathD)is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments.Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling.In neutral pH environments,the cathD precursor directly dephosphorylates and activates the actin-severing protein cofilin independent of its proteolytic activity,whereas mature cathD degrades cofilin in acidic pH conditions.During development,cathD complements the canonical cofilin phosphatase slingshot and regulates the morphogenesis of actin-based structures.Moreover,suppression of cathD phosphatase activity leads to defective actin organization and cytokinesis failure.Our findings identify cathD as a dual-function molecule,whose functional switch is regulated by environmental pH and its maturation state,and reveal a novel regulatory role of cathD in actin-based cellular processes. 关键词：CATHEPSIN CANONICAL traditionally

相关文献

参考文献（45）
引证文献（1）
耦合文献（3）

参考文献(45)

引证文献(1)

耦合文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

The noncanonical role of the protease cathepsin D as a cofilin phosphatase

参考文献(45)

引证文献(1)

耦合文献(3)

用户提示