The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

查看全文 作　　者：Yujie [1,2,3]Ren;Ting [2,4,5]Shu;Di [2,4]Wu;Jingfang [2,4]Mu;Chong [1,2,3]Wang;Muhan [2,4]Huang;Yang [2,4,5]Han;Xue-Yi [2,6]Zhang;Wei [1]Zhou;Yang [2,4,5,7]Qiu;Xi [2,3,4,5,6,7]Zhou

机构地区：[1]Center for Precision Translational Medicine of Wuhan Institute of Virology&Guangzhou Women and Children’s Medical Center,Guangzhou Women and Children’s Medical Center,Guangzhou,Guangdong,510120,China;[2]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences(CAS),Wuhan,Hubei,430071,China;[3]Center for Precision Translational Medicine of Wuhan Institute of Virology&Guangzhou Women and Children’s Medical Center,Wuhan Institute of Virology,CAS,Wuhan,Hubei,430071,China;[4]Joint Laboratory of Infectious Diseases and Health,Wuhan Institute of Virology&Wuhan Jinyintan Hospital,CAS,Wuhan,Hubei,430023,China;[5]Center for Translational Medicine,Wuhan Jinyintan Hospital,Wuhan,Hubei,430023,China;[6]State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan,Hubei,430072,China;[7]University of Chinese Academy of Sciences,Beijing,100049,China

出　　处：《Cellular & Molecular Immunology》索引2020年第17卷第8期,共3页

基　　金：This work was supported by the Strategic Priority Research Program of CAS(XDB29010300 to X.Z.);National Science and Technology Major Project(2018ZX10101004 to X.Z.);National Natural Science Foundation of China(81873964 to Y.Q.,31800140 to J.M.and 31670161 to X.Z.);China Postdoctoral Science Foundation(2019M660198 to Y.R.);Grant from the CAS Youth Innovation Promotion Association(2020332 to Y.Q.). 摘　　要：Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the ongoing pandemic of Coronavirus Disease 2019.SARS-CoV-2 belongs to the genus Betacoronavirus of the Coronaviridae family,which includes SARS-CoV and Middle East respiratory syndrome coronavirus.1,2 Coronavirus-encoded accessory proteins play critical roles in virus–host interactions and the modulation of host immune responses,thereby contributing to coronaviral pathogenicity via different strategies.3 However,the functions of SARS-CoV-2-encoded accessory proteins are not well understood.Apoptosis is a predominant type of programmed cell death,and has been recognized as an important host antiviral defense mechanism that controls viral infection and regulates the inflammatory response.4,5 Previous studies have reported that the SARS-CoV-encoded accessory protein ORF3a can induce apoptosis in cells,6,7 leading to the question of whether SARS-CoV-2 ORF3a also has pro-apoptotic activity.Here,we investigated the potential apoptosis-inducing activity of SARS-CoV-2 ORF3a in different cell lines and compared the pro-apoptotic activities of SARS-CoV-2 ORF3a with those of SARS-CoV ORF3a using the same system. 关键词：RESPIRATORY ACUTE thereby

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The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

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