Bioconjugated Silica Nanoparticles: Development and Applications

查看全文 作　　者：Lin [1]Wang;Wenjun [2,3]Zhao;Weihong [3]Tan

机构地区：[1]Lilly Research Laboratories,Eli Lilly and Company,Indianapolis,IN 46285,USA;[2]Chinese Academy of Inspection and Quarantine,Huixinli 241,Chaoyang District,Beijing 100029,China;[3]Center for Research at the Bio/Nano Interface,Department of Chemistry and Department of Physiology and Functional Genomics,Shands Cancer Center,UF Genetics Institute and McKnight Brain Institute,University of Florida,Gainesville,FL 32611-7200,USA

出　　处：《Nano Research》索引2008年第1卷第2期,共17页

基　　金：US NIH grants,NSF NIRT and State of Florida Center of Excellence for nano-biosensors。 摘　　要：Advanced bioanalysis,including accurate quantitation,has driven the need to understand biology and medicine at the molecular level.Bioconjugated silica nanoparticles have the potential to address this emerging challenge.Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery,have also been found for silica nanoparticles.In this review,we describe the synthesis,bioconjugation,and applications of silica nanoparticles in different bioanalysis formats,such as selective tagging,barcoding,and separation of a wide range of biomedically important targets.Overall,we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology,genomics,proteomics and medicine. 关键词：Nanoscience NANOTECHNOLOGY silica nanoparticles BIOANALYSIS BIOMEDICINE

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Bioconjugated Silica Nanoparticles: Development and Applications

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