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Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing

查看全文 作　　者：Guopu [1]Chen;Yunru [2]Yu;Xiuwen [1]Wu;Gefei [1]Wang;Guosheng [1]Gu;Feng [1]Wang;Jianan [1]Ren;Huidan [3]Zhang;Yuanjin [1,2]Zhao 高影响力作者 机构地区：[1]Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China;[2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China;[3]School of Engineering and Applied Sciences and Department of Physics,Harvard University,Cambridge,Massachusetts 02138,USA高影响力机构 出　　处：《Research》索引2019年第1期,共11页高影响力期刊 基　　金：This work was supported by the National Key Research and Development Program of China(2017YFA0700404);the National Science Foundation of China(Grant Nos.81870396,81801971,and 51522302);the NSAF Foundation of China(grant U1530260);Projects of Jiangsu Social Development(BE2016752,BE2017722,BE2017725,and BE2018707);Innovation Project of Military Medicine(16CXZ007),Distinguished Scholars Foundation of Jiangsu Province(JCRCB2016006);the Scientifc Research Foundation of Southeast University。 摘　　要：Niacin metal-organic frameworks(MOFs)encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfuidic electrospray approach for wound healing.As the alginate shells were bacteriaresponsively degradable,the niacin MOFs encapsulated microcapsules could intelligently,controllably,and programmably release calcium,copper,and zinc ions,depending on the degree of infections.Te released ions could not only kill microbes by destroying their membrane and inducing the outfow of nutrient substance,but also activate copper/zinc superoxide dismutase(Cu/ZnSOD)to eliminate oxygen free radicals and rescue the cells from oxidative stress injury.Furthermore,the simultaneously released niacin could promote hemangiectasis and absorption of functional metal ions.Tus,the niacin MOFs encapsulated microcapsules were imparted with outstanding antibacterial,antioxidant,and angiogenesis properties.Based on an in vivo study,we have also demonstrated that the chronic wound healing process of an infected full-thickness skin defect model could be signifcantly enhanced by using the niacin MOFs encapsulated microcapsules as therapeutic agent.Terefore,the microfuidic electrospray niacin MOFs encapsulated microcapsules are potential for clinical applications. 关 键 词：properties SHELLS copper
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