Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

查看全文 作　　者：X Luís Deán-[1]Ben;Thomas F [1,2]Fehm;Steven J [1]Ford;Sven [1]Gottschalk;Daniel [1,2]Razansky

机构地区：[1]Institute for Biological and Medical Imaging(IBMI),Helmholtz Center Munich,85764 Neuherberg,Germany;[2]School of Medicine and School of Bioengineering,Technical University of Munich,81675 Munich,Germany

出　　处：《Light(Science & Applications)》索引2016年第5卷第1期,共8页

基　　金：funding from the European Research Council under grant agreements ERC-2010-StG-260991 and ERC-2015-CoG-682379;the Human Frontier Science Program(HFSP)Grant RGY0070/2016. 摘　　要：Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms,disease state and progression.Optoacoustic imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue observations.Yet,efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of view.Herein,we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched highresolution contrast across multiple spatiotemporal scales.In vivo experiments in mice demonstrate a wide range of dynamic imaging capabilities,from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image quality.The newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural,functional and molecular imaging. 关键词：multi-scale dynamics multi-spectral imaging optoacoustic tomography real-time imaging whole-body imaging

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Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

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