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Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair

查看全文 作　　者：Liping [1]Wang;Nicholas [2]J.Long;Lihua [1]Li;Yao [3]Lu;Mei [3]Li;Jiangkun [1]Cao;Yu [3]Zhang;Qinyuan [1]Zhang;Shanhui [1]Xu;Zhongmin [1]Yang;Chuanbin [4,5]Mao;Mingying [1]Peng 高影响力作者 机构地区：[1]The State Key Laboratory of Luminescent Materials and Devices,Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices,Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques,School of Materials Science and Engineering,South China University of Technology,510641 Guangzhou,China;[2]Department of Chemistry,Imperial College London,South Kensington,London SW72AZ,UK;[3]Guangdong Key Lab of Orthopedic Technology and Implant Materials,Department of Orthopedics,Guangzhou General Hospital of Guangzhou Military Command,111 Liuhua Road,510010 Guangzhou,China;[4]Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center,University of Oklahoma,Norman,OK 73072,USA;[5]School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China高影响力机构 出　　处：《Light(Science & Applications)》索引2018年第7卷第1期,共13页高影响力期刊 基　　金：financial support from the Program for Innovative Research Team in University of Ministry of Education of China(Grant No.IRT_17R38);the National Natural Science Foundation of China(Grant No.51672085);the Key Program of Guangzhou Scientific Research Special Projects(Grant No.201607020009);the Joint Fund of Ministry of Education of China;the Fundamental Research Funds for the Central Universities. 摘　　要：Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials. 关 键 词：GLASSES BISMUTH TREATMENT
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