Localization optoacoustic tomography

查看全文 作　　者：X Luís Dean-[1]Ben;Daniel [1,2]Razansky

机构地区：[1]Institute for Biological and Medical Imaging,Helmholtz Center Munich,Neuherberg 85764,Germany;[2]School of Medicine and School of Bioengineering,Technical University of Munich,Munich 81675,Germany

出　　处：《Light(Science & Applications)》索引2018年第7卷第1期,共5页

基　　金：supported in part by the European Research Council Grant ERC-2015-CoG-682379. 摘　　要：Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues.Herein,we introduce a new concept of localization optoacoustic tomography(LOT)that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles.We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions.Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters,LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation. 关键词：acoustic diffraction limited-view effects LOCALIZATION optoacoustic imaging photoacoustic imaging SUPER-RESOLUTION

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Localization optoacoustic tomography

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