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In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets

查看全文 作　　者：Pengfei [1,3]Zhang;Lei [2]Li;Li [2]Lin;Junhui [2]Shi;Lihong [2]V.Wang 高影响力作者 机构地区：[1]Optical Imaging Laboratory,Department of Biomedical Engineering,Washington University in St.Louis,St.Louis,Missouri 63130,USA;[2]Caltech Optical Imaging Laboratory,Andrew and Peggy Cherng Department of Medical Engineering,Department of Electrical Engineering,California Institute of Technology,1200 E.California Blvd.,MC 138-78,Pasadena,CA 91125,USA;[3]Present address:School of Precision Instruments and Optoelectronics Engineering,Tianjin University,Tianjin 300072,China高影响力机构 出　　处：《Light(Science & Applications)》索引2019年第8卷第1期,共9页高影响力期刊 基　　金：sponsored by the NIH grants DP1 EB016986(NIH Director’s Pioneer Award);R01 CA186567(NIH Director’s Transformative Research Award);U01 NS090579(BRAIN Initiative);U01 NS099717(BRAIN Initiative). 摘　　要：Photoacoustic(PA)computed tomography(PACT)is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast,high resolution,and deep penetration in biological tissues.However,the spatial resolution of PACT is limited by acoustic diffraction.Here,we report in vivo superresolution PACT,which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets that are flowing in blood vessels.The droplets were prepared by dissolving hydrophobic absorbing dye in oil,followed by mixing with water.The dyed droplets generate much higher-amplitude PA signals than blood and can flow smoothly in vessels;thus,they are excellent tracers for localization-based superresolution imaging.The in vivo resolution enhancement was demonstrated by continuously imaging the cortical layer of a mouse brain during droplet injection.The droplets that were flowing in the vessels were localized,and their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details.An improvement in spatial resolution by a factor of 6 has been realized in vivo by the droplet localization technique. 关 键 词：technique. RESOLUTION DYE
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