Storm of soluble immune checkpoints associated with disease severity of COVID-19

查看全文 作　　者：Yaxian [1]Kong;Yu [2]Wang;Xueying [3]Wu;Junyan [1]Han;Guoli [1]Li;Mingxi [1]Hua;Kai [1]Han;Henghui [1]Zhang;Ang [4]Li;Hui [1]Zeng

机构地区：[1]Institute of Infectious Diseases,Beijing Key Laboratory of Emerging Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;[2]Department of Respiratory Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;[3]Immupeutics Medicine Institute,Beijing 100191,China;[4]Department of Intensive Care Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China

出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共3页

基　　金：supported by Capital Clinical Characteristic Application(Z171100001017052);National Key Sci-Tech Special Project of China(2018ZX10302207);Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support(ZYLX201802);Beijing Hospital Authority(DFL20191801). 摘　　要：Dear Editor,As the outbreak of coronavirus disease 2019(COVID-19)turns into a pandemic,it has literally caused a worldwide public health crisis.Progressive lymphopenia,especially in T cells,was a prominent clinical feature of severe COVID-19 in addition to dyspnea,hypoxemia,acute respiratory distress,and cytokine release syndrome.1 Recently,several studies revealed a correlation between T cell depletion and increased expression levels of several inhibitory checkpoint molecules on T cells in severe COVID-19 cases.2 Classically,inhibitory checkpoint molecules have been documented as key factors for regulating T cell exhaustion in a variety of chronic viral infections and tumors.Recent studies further implied a pivotal role of inhibitory checkpoint molecules in the pathophysiology of acute viral infections,such as Ebola virus or hantavirus infection.Of note,soluble isoforms of checkpoints can be produced by cleavage of membrane-bound proteins or by alternative splicing of mRNA and competitively regulate the functions of their membrane-bound counterparts.3 Thus it is of great interest to determine whether soluble checkpoint molecules are involved in immune regulation and severity of COVID-19. 关键词：SEVERITY acute DISTRESS

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Storm of soluble immune checkpoints associated with disease severity of COVID-19

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