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Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer

查看全文 作　　者：Xiaoling [1,2,3]Song;Maolan [1,2]Li;Wenguang [2,4]Wu;Wei [1,2,3]Dang;Yuan [2,3,4]Gao;Rui [2,3,4]Bian;Runfa [1,2]Bao;Yunping [1,2,3]Hu;Defei [5]Hong;Jun [1,2]Gu;Yingbin [1,2,3,4]Liu 高影响力作者 机构地区：[1]Department of General Surgery and Laboratory of General Surgery,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,1665 Kongjiang Road,200092 Shanghai,China;[2]Shanghai Key Laboratory of Biliary Tract Disease Research,Shanghai Jiao Tong University,200127 Shanghai,China;[3]State Key Laboratory of Oncogenes and Related Genes,Shanghai Jiao Tong University,160 Pujian Road,200127 Shanghai,China;[4]Department of Biliary-Pancreatic Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,160 Pujian Road,200127 Shanghai,China;[5]Department of General Surgery,Sir Run Run Shaw Hospital,The Medicine School of Zhejiang University,East Qinchun Road,310020 Hangzhou,Zhejiang Province,China高影响力机构 出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共3页高影响力期刊 基　　金：supported by Shanghai Key Laboratory of Biliary Tract Disease Research Foundation(17DZ2260200);the National Natural Science Foundation of China(Nos.81572819,91940305,81773043,91440203,81702315);the Peak Plateau Discipline Construction Project of Shanghai Jiao Tong University School of medicine(No.20181808);the development fund for Shanghai talents(No.201608);Shanghai Sailing Program(17YF1411700);the Program of Shanghai Academic Research Leader(No.19XD1422700);the Precision Medicine Research Program of Shanghai Jiao Tong University School of Medicine(Nos.15ZH4003,DKY201507)。 摘　　要：Dear Editor,Gallbladder cancer(GBC),the most common malignant tumor of the biliary tract,is a highly invasive form of cancer.Surgical resection is currently the first line approach to effectively treat GBC;however,very few patients have the opportunity to receive radical surgical treatment due to lack of obvious symptoms.1 The median survival of patients with GBC is only 12 months and 5-year survival rate is<5%,indicating GBC is extremely poor prognosis.Therefore,it is urgent to identify novel key molecules that can potentially serve as early diagnostic biomarkers and/or therapeutic targets.The current study focused on the potential role of bone morphogenetic protein 2 inducible kinase(BMP2K),a serine/threonine kinase,which was recently identified as clathrin-coated vesicle-associated protein in the development of GBC;the outcome may hold diagnostic and therapeutic promising for clinical practice. 关 键 词：cancer BMP2 GALLBLADDER
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