Exosomes:key players in cancer and potential therapeutic strategy

查看全文 作　　者：Jie [1,2]Dai;Yangzhou [1,2]Su;Suye [1,2]Zhong;Li [1,2]Cong;Bang [1,2]Liu;Junjun [3]Yang;Yongguang [4]Tao;Zuping [1,2]He;Chao [5]Chen;Yiqun [1]Jiang

机构地区：[1]The Key Laboratory of Model Animal and Stem Cell Biology in Hunan Province,Hunan Normal University,Changsha 410013 Hunan,China;[2]School of Medicine,Hunan Normal University,Changsha 410013 Hunan,China;[3]Center for Joint Surgery,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China;[4]Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education,Department of Pathology,Xiangya Hospital,School of Basic Medicine,Central South University,Changsha 410078 Hunan,China;[5]School of Medicine&Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210013 Jiangsu,China

出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共10页

基　　金：supported by the National Natural Science Foundation of China(81802785[Y.J.]);Hunan Provincial Natural Science Foundation of China(2020JJ5382[Y.J.],2020JJ5381[L.C.]). 摘　　要：Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication.The components of exosomes,including proteins,DNA,mRNA,microRNA,long noncoding RNA,circular RNA,etc.,which play a crucial role in regulating tumor growth,metastasis,and angiogenesis in the process of cancer development,and can be used as a prognostic marker and/or grading basis for tumor patients.Hereby,we mainly summarized as followed:the role of exosome contents in cancer,focusing on proteins and noncoding RNA;the interaction between exosomes and tumor microenvironment;the mechanisms that epithelial-mesenchymal transition,invasion and migration of tumor affected by exosomes;and tumor suppression strategies based on exosomes.Finally,the application potential of exosomes in clinical tumor diagnosis and therapy is prospected,which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic. 关键词：EXOSOMES INVASION DIAGNOSIS

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Exosomes:key players in cancer and potential therapeutic strategy

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