Proteomics provides individualized options of precision medicine for patients with gastric cancer

查看全文 作　　者：Wenwen [1]Huang;Dongdong [2,8]Zhan;Yazhuo [3]Li;Nairen [2]Zheng;Xin [2,10]Wei;Bin [4]Bai;Kecheng [5]Zhang;Mingwei [2]Liu;Xuefei [2]Zhao;Xiaotian [2]Ni;Xia [2]Xia;Jinwen [2]Shi;Cheng [1]Zhang;Zhihao [1]Lu;Jiafu [6]Ji;Juan [4]Wang;Shiqi [4]Wang;Gang [4]Ji;Jipeng [4]Li;Yongzhan [4]Nie;Wenquan [5]Liang;Xiaosong [5]Wu;Jianxin [5]Cui;Yongsheng [7]Meng;Feilin [7]Cao;Tieliu [8]Shi;Weimin [2]Zhu;Yi [2]Wang;Lin [5]Chen;Qingchuan [4]Zhao;Hongwei [3]Wang;Lin [1]Shen;Jun [2,9]Qin

机构地区：[1]Department of Gastrointestinal Oncology,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Peking University Cancer Hospital and Institute,Beijing 100142,China;[2]State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China;[3]Department of Pathology,The Fourth Medical Center of PLA General Hospital,Beijing 100048,China;[4]State Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases and Department of Digestive Surgery,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi’an 710032,China;[5]Department of General Surgery&Institute of General Surgery,Chinese PLA General Hospital First Medical Center,Beijing 100853,China;[6]Department of Gastrointestinal Surgery,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Peking University Cancer Hospital and Institute,Beijing 100142,China;[7]Department of tumor biobank,Shanxi Cancer Hospital,Taiyuan 030013,China;[8]Center for Bioinformatics and Computational Biology,Shanghai Key Laboratory of Regulatory Biology,Institute ofBiomedical Sciences and School of Life Sciences,East China Normal University,Shanghai 200241,China;[9]State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development,School of Life Sciences,Institute of Biomedical Sciences,Fudan University,Shanghai 200433,China;[10]Life Sciences Institute,Zhejiang University,Hangzhou 310058,China

出　　处：《Science China(Life Sciences)》索引2021年第64卷第8期,共13页

基　　金：supported by the National Key Research and Development Program of China(2017YFC1308900,2017YFC0908404,2018YFA0507503,2017YFA0505103);Beijing Municipal Government Key Research and Development Program(Z181100001918020,Z161100002616036);the National Natural Science Foundation of China(31870828,81972790,81672319);the Guangdong Provincial Key R&D Programmes(2019B020229002);the Science and Technology Program of Guangzhou(201902020009);the National Key Basic Research Program of China(2014CBA02002);the National Key Technology Support Program(2015BAI13B07). 摘　　要：While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. 关键词：PATIENTS CHEMOTHERAPY cancer

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Proteomics provides individualized options of precision medicine for patients with gastric cancer

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