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sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator

查看全文 作　　者：Yawen [1]Song;Hui [1]Sun;Kailiang [1]Wu;Jianke [1]Lyu;Jingyue [1]Zhang;Feng [1]Gu;Yongjie [1]Ma;Beibei [1]Shen;Chijuan [1]Wang;Xiaojiao [1]Chen;Jing [1]Xu;Weidong [1]Li;Fangfang [1]Liu;Li [1]Fu 高影响力作者 机构地区：[1]Department of Breast Cancer Pathology and Research Laboratory,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjin’s Clinical Research Center for Cancer,Key Laboratory of Breast Cancer Prevention and Therapy,Tianjin Medical University,Ministry of Education,Breast Cancer Innovation Team of the Ministry of Education,State Key Laboratory of Breast Cancer Research,Tianjin 300060,China高影响力机构 出　　处：《Cancer Biology & Medicine》索引2021年第18卷第2期,共13页高影响力期刊 基　　金：supported by funding from the National Natural Science Foundation of China (Grant Nos. 81672637 and 81872164)。 摘　　要：Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. 关 键 词：Invasive micropapillary carcinoma polarity reversal diagnostic indicator EMA sLe^(x)
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