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Factors affecting complications development and mortality after single lung transplant

查看全文 作　　者：Metodija [1,2]Sekulovski;Bilyana [1]Simonska;Milena [3]Peruhova;Boris [4]Krastev;Monika Peshevska-[3]Sekulovska;Lubomir [5]Spassov;Tsvetelina [6]Velikova 高影响力作者 机构地区：[1]Department of Anesthesiology and Intensive care,University Hospital Lozenetz,Sofia 1407,Bulgaria;[2]Medical Faculty,Sofia University St.Kliment Ohridski,Sofia 1407,Bulgaria;[3]Department of Gastroenterology,University Hospital Lozenetz,Sofia 1407,Bulgaria;[4]Department of Clinical Oncology,MHAT Hospital for Women Health Nadezhda,Sofia 1330,Bulgaria;[5]Department of Cardiothoracic Surgery,University Hospital Lozenetz,Sofia 1431,Bulgaria;[6]Department of Clinical Immunology,University Hospital Lozenetz,Sofia 1407,Bulgaria高影响力机构 出　　处：《World Journal of Transplantation》索引2021年第11卷第8期,共15页高影响力期刊 摘　　要：Lung transplantation(LT)is a life-saving therapeutic procedure that prolongs survival in patients with end-stage lung disease.Furthermore,as a therapeutic option for high-risk candidates,single LT(SLT)can be feasible because the immediate morbidity and mortality after transplantation are lower compared to sequential single(double)LT(SSLTx).Still,the long-term overall survival is,in general,better for SSLTx.Despite the great success over the years,the early post-SLT period remains a perilous time for these patients.Patients who undergo SLT are predisposed to evolving early or late postoperative complications.This review emphasizes factors leading to post-SLT complications in the early and late periods including primary graft dysfunction and chronic lung allograft dysfunction,native lung complications,anastomosis complications,infections,cardiovascular,gastrointestinal,renal,and metabolite complications,and their association with morbidity and mortality in these patients.Furthermore,we discuss the incidence of malignancy after SLT and their correlation with immunosuppression therapy. 关 键 词：Lung transplantation Single lung transplant Primary graft dysfunction Native lung complications Technical transplant complications Vascular transplant complications Graft rejection De novo malignancy
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