Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

查看全文 作　　者：Hao [1]Wang;Yu [1]Yuan;Mingzhong [2,3,4]Xiao;Li [5,6]Chen;Youyun [2,3,4]Zhao;Haiwei [5]Zhang;Pinpin [1]Long;Yana [2,3,4]Zhou;Xi [2,3,4]Xu;Yanshou [1]Lei;Bihao [5,6]Wu;Tingyue [1]Diao;Hao [1]Cai;Li [1]Liu;Zuoyu [2,3,4]Shao;Jingzhi [2,3,4]Wang;Yansen [1]Bai;Kai [1]Wang;Miao [2,3,4]Peng;Linlin [7]Liu;Shi [7]Han;Fanghua [7]Mei;Kun [7]Cai;Yake [1]Lei;An [1]Pan;Chaolong [1]Wang;Rui [3]Gong;Xiaodong [2,3,4]Li;Tangchun [1]Wu

机构地区：[1]Ministry of Education and State Key Laboratory of Environmental Health(Incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China;[2]Hepatic Disease Institute,Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan,China;[3]Affiliated Hospital of Hubei University of Chinese Medicine,Wuhan,China;[4]Hubei Province Academy of Traditional Chinese Medicine,Wuhan,China;[5]CAS Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,China;[6]University of Chinese Academy of Sciences,Beijing,China;[7]Hubei Provincial Center for Disease Control and Prevention,Wuhan,China

出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第7期,共3页

基　　金：supported by grants from the Fundamental Research Funds for the Central Universities(2019kfyXMBZ015);the 111 Project(Prof.Wu),the Fellowship of China Postdoctoral Science Foundation(2020T130034ZX,and 2020T130035ZX);the National Key Research and Development Plan Program of China(2020YFC0860800);the Revitalization Projects after the COVID-19 Plague of the China Association for Science and Technology(20200608CG111311);the Emergency Research Projects for COVID-19 Prevention and Control of the Wuhan Health Commission(EG20M01). 摘　　要：COVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international economy.Understanding the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 months.Moreover,with limited observations over 9 months(n<100),2,7,8 several studies have produced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently needed.Therefore,we repeatedly tested IgM,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in COVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up. 关键词：INFECTION SEVERITY MORTALITY

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Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

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