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A combination of immunoadjuvant nanocomplexes and dendritic cell vaccines in the presence of immune checkpoint blockade for effective cancer immunotherapy

查看全文 作　　者：Manh-Cuong [1,2,3]Vo;Seo-Yeon [2,3]Ahn;Tan-Huy [2]Chu;Saji [4]Uthaman;Shammer [5]Pillarisetti;Tung Nguyen Thanh [6]Uong;Thangaraj Jaya [2]Lakshmi;Mihee [3]Kim;Ga-Young [3]Song;Sung-Hoon [2,3]Jung;Deok-Hwan [3]Yang;Jae-Sook [3]Ahn;Hyeoung-Joon [3]Kim;In-Kyu [5]Park;Je-Jung [2,3]Lee 高影响力作者 机构地区：[1]Institute of Research and Development,Duy Tan University,Danang,Vietnam;[2]Research Center for Cancer Immunotherapy,Chonnam National University Hwasun Hospital,Hwasun,Jeollanamdo,Republic of Korea;[3]Department of Hematology-Oncology,Chonnam National University Hwasun Hospital,Chonnam National University Medical School,Gwangju,Republic of Korea;[4]Department of Polymer Science and Engineering,Chungnam National University,Daejeon,Republic of Korea;[5]Department of Biomedical Science,Chonnam National University Medical School,Gwangju,Republic of Korea;[6]Department of Radiation Oncology,Chonnam National University Hwasun Hospital,Chonnam National University Medical School,Gwangju,South Korea View author publications高影响力机构 出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第6期,共3页高影响力期刊 基　　金：supported by grants from the Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education,Science and Technology(2018R1A5A2024181,2020R1A2C2010098). 摘　　要：Nanovaccines are used as delivery platforms for antigens and adjuvants, which activate antigen-presenting cells (APCs) and enhance anticancer immune responses.1,2 Researchers have recently developed a self-assembled nanocomplex using a polysorbitol-co-PEI (PSPEI) polymer complexed with poly(I:C) (PIC). By binding to different surface proteins, this nanocomplex enhances the intracellular delivery of cargos and induces potent anticancer immune responses against melanoma cells.3 We have previously demonstrated that PD-1/PD-L1 blockade enhanced the efficacy of DC-based cancer immunotherapy.4,5 Moreover, the combination of nanomedicines and PD-L1 blockade has been reported to enhance CD8+ T cell activation and inhibit immunosuppressive cells within the tumor microenvironment.6 In the present study, we investigated the therapeutic efficacy of a combinatorial treatment comprising the immunoadjuvant nanocomplex PSPEI-PIC, a DC vaccine, and PD-L1 blockade in a murine colon cancer model. 关 键 词：ADJUVANT vaccines IMMUNOTHERAPY
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