New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

查看全文 作　　者：Fan [1]Xiao;Man [2]Han;Ke [3]Rui;Xiangyan [4]Ai;Jie [3]Tian;Wen [5]Zhang;Futao [4]Zhao;Yan [5]Zhao;Quan [2]Jiang;Liwei [1]Lu

机构地区：[1]Department of Pathology and Shenzhen Institute of Research and Innovation,The University of Hong Kong,Chongqing International Institute for Immunology,Hong Kong,China;[2]Division of Rheumatology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,China;[3]Department of Laboratory Medicine,Affiliated Hospital of Jiangsu University and Jiangsu Key Laboratory of Laboratory Medicine,Zhenjiang,China;[4]Department of Rheumatology,Shanghai Ninth People’s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;[5]Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing,China

出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第6期,共3页

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82071817 and 82004171);the Chongqing International Institute for Immunology(2020YJC10);the Hong Kong Research Grants Council(17149716);Fundamental Research Funds for Central Public Welfare Research Institutes(ZZ13-YQ-033-C1);the Young Elite Scientist Sponsorship Program of CACM(CACM-2020-QNRC2-05);HKU Seed Funding for Strategic Interdisciplinary Research Scheme. 摘　　要：Follicular helper T (Tfh) cells play a key role in driving B cell activation and differentiation during germinal center reactions in immune responses and autoimmune development, and these cells are characterized by high expression of CXCR5, PD1, ICOS, IL-21 and BCL6. Increasing evidence indicates that the functional dysregulation of Tfh cells contributes to the pathogenesis of autoimmune diseases, including primary Sjögren’s syndrome (pSS), which is a common autoimmune disease characterized by lymphocytic infiltration and tissue inflammation in salivary glands (SGs) and lacrimal glands that leads to dry mouth and dry eyes.1 Here, we provide a brief commentary on recent advances in understanding the Tfh cell response with a focus on new insights into Tfh cell regulation and therapeutic implications in autoimmune diseases. 关键词：AUTOIMMUNE PATHOGENESIS PD1

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New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

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