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Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study

查看全文 作　　者：Da-Peng [1]Mou;Yuan-Bo [1,2]Liang;Su-Jie [2]Fan;Yi [1]Peng;Ning-Li [1]Wang;Ravi [3,4]Thomas 高影响力作者 机构地区：[1]Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology&Visual Science Key Lab,Beijing 100730,China;[2]Handan Eye Hospital,Handan 056001,Hebei Province,China;[3]Queensland Eye Institute,Brisbane 4343,Australia;[4]University of Queensland,Brisbane 4343,Australia高影响力机构 出　　处：《International Journal of Ophthalmology(English edition)》索引2021年第14卷第8期,共6页高影响力期刊 基　　金：Supported in part by the Ministry of Science and Technology of the National“Eleventh Five-Year”Science and Technology Program in China(No.2007BAI18B08);Beijijng Municipal Science and Technology Commission,Capital Characteristic Clinic Project(No.Z171100001017040)。 摘　　要：AIM:To report the progression rate(PR)to primary angle closure(PAC)following laser peripheral iridotomy(LPI)in PAC suspects(PACS).METHODS:Prospective,randomized controlled interventional clinical trial conducted at the Handan Eye Hospital,China.Totally 134 bilateral PACS,defined as non-visibility of the posterior trabecular meshwork for≥180 degrees on gonioscopy were randomly assigned to undergo LPI in one eye.Gonioscopy and Goldmann applanation tonometry were performed prior to,on day 7 and 12 mo post LPI.RESULTS:Eighty of 134 patients(59.7%)could be followed up at one year.The mean intraocular pressure(IOP)in treated eyes was 15.9±2.6 mm Hg at baseline,15.4±3.0 mm Hg on day 7;16.5±2.9 mm Hg at one month,and 15.5±2.9 mm Hg at 12 mo;the IOP in untreated eyes was similar(P=0.834).One or more quadrants of the angle opened in 93.7%of the LPI treated eyes,but 67.0%(53/79)remained closed in two or more quadrants.The PR to PAC in untreated eyes was 3.75%and one developed acute angleclosure glaucoma(AACG);the PR to PAC in treated eyes was 2.5%and none had developed peripheral anterior synechia(PAS)or AACG.CONCLUSION:LPI can open some of the occludable angle in the majority of eyes with PACS,but 67%continue to have non-visibility of the trabecular meshwork for over 180 degrees. 关 键 词：primary angle-closure suspects anterior chamber angle laser peripheral iridotomy intraocular pressure
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