Circulating tumor cells and drug history in primary breast cancer patients

查看全文 作　　者：Silvia [1,2]Jurisova;Marián [2,3]Karaba;Gabriel [4]Minarik;Juraj [2,5]Benca;Tatiana [4]Sedlackova;Daniela [1]Manasova;Katarina [1,2]Kalavska;Daniel [2,3]Pindak;Jozef [1,2]Mardiak;Michal [1,2]Mego 机构地区：[1]nd Department of Oncology,Faculty of Medicine,Comenius University,Bratislava 83310,Slovakia;[2]National Cancer Institute,Bratislava 83310,Slovakia;[3]Slovak Medical University,Bratislava 83101,Slovakia;[4]Institute of Molecular Biomedicine,Faculty of Medicine,Comenius University,Bratislava 83172,Slovakia;[5]Department of Medicine,St.Elizabeth University,Bratislava 81250,Slovakia 出　　处：《Cancer Drug Resistance》索引2020年第3卷第1期,共12页 基　　金：This publication is the result of the implementation of projects no.APVV-16-0010 and APVV-14-0327 funded by the Slovak Research and Development Agency. 摘　　要：Aim:Different types of chronic medication may affect breast cancer prognosis.Circulating tumor cells(CTCs)play an important role in cancer metastasis formation.There is no evidence of how chronic medication affects CTCs and breast cancer prognosis.The aim of this study was to evaluate association between chronic medication and CTCs in patients with primary breast cancer.Methods:This study involved 414 patients with stage I-III primary breast cancer.Chronic drug history was collected from patients’medical records and included all drugs that were prescribed for patients over at least the last 6 months prior to CTCs evaluation.CTCs were detected using a quantitative real-time polymerase chain reaction(qRT-PCR)-based method at the time of breast surgery.Results:There was no association between CTCs,including their different subpopulations and chronic medication.Chronic medication using angiotensin-converting-enzyme inhibitors(ACEi),metformin,and insulin were associated with inferior disease-free survival(HR=0.49,95%CI 0.26-0.94,P=0.007 for ACEi;HR=0.27,95%CI 0.08-0.91,P<0.001 for metformin;and HR=0.12,95%CI 0.01-2.91,P<0.001 for insulin)and this was most pronounced in patients with epithelial to mesenchymal transition(CTC_EMT)phenotype.In multivariate analysis,chronic administration of metformin and/or insulin was an independent predictor of inferior outcome.Conclusion:Our findings show that there was no association between chronically used medication and CTCs in primary breast cancer patients.However,administration of ACEi,metformin,and/or insulin could negatively affect prognosis of patients with CTC_EMT. 关 键 词：Circulating tumor cells chronic medication epithelial-to-mesenchymal transition early breast cancer