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The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP

查看全文 作　　者：Xiaolin [1,2]Zhu;Yiping [1]Zhang;Qingyu [1]Luo;Xiaowei [1]Wu;Furong [1]Huang;Tong [3]Shu;Yong [4]Wan;Hongyan [1,2]Chen;Zhihua [1]Liu 高影响力作者 机构地区：[1]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;[2]Key Laboratory of Cancer and Microbiome,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;[3]Department of Gynecological Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;[4]Department of Obstetrics and Gynecology,Deportment of Pharmacology,The Robert H.Lurie Comprehensive Cancer Center,Northwestern University Feinberg School of Medicine,Chicago 60611 IL,USA高影响力机构 出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第8期,共3页高影响力期刊 基　　金：This study was supported by funding from the National Key R&D Program of China(2020YFA0803300);the National Natural Science Foundation of China(82030089);the CAMS Innovation Fund for Medical Sciences(2016-I2M-1-001,2019-12M-1-003,2019-I2M-2-004);the Non-profit Central Research Institute Fund of CAMS(2019PT310027). 摘　　要：Dear Editor,Chemoresistance is a major problem in the treatment of ovarian cancer patients and leads to poor prognosis,but its underlying mechanism remains elusive.Accumulating evidences have found that the aberrant regulation of the protein ubiquitination pathway plays an essential role in ovarian cancer chemoresistance.13 However,it is unclear whether and how deubiquitinase-USP11 involves in ovarian cancer chemoresistance. 关 键 词：UBIQUITIN cancer PROGNOSIS
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