Access to Polycyclic lndol(en)ines via Base-Catalyzed Intramolecular Dearomatizing 3-Alkenylation of Alkynyl Indoles

查看全文 作　　者：Lin [1]Lu;Zuoliang [2]Zheng;Yongjie [1]Yang;Bo [2,3]Liu;Biaolin [1]Yin

机构地区：[1]Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,Guangdong 510640,China;[2]The Second Clinical Medical College,and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China;[3]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Journal of Chemistry》索引2021年第39卷第8期,共6页

基　　金：This work was supported by grants from the National Program on Key Research Project(No.2016YFA0602900);the National Natural Science Foundation of China(Nos.21572068 and 21871094);the Guangdong Natural Science Foundation(No.2017A030312005);the Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine[(2014)NO.32];the Special Foundation of Guangzhou Key Laboratory(No.202002010004). 摘　　要：Polycyclic in doli nes and in dole nines were synthesized via base-catalyzed in tramolecular dearomatizi ng 3-alke nylation reacti ons of al-kynyl in doles 1 at room temperature.The base enhan ced the nu cleophilicity of the carb on at the 3-position of the indole moiety,facilitating an exclusive S-exo-dig cyclization reaction with the alkyne to form spiroindolenines2. 关键词：DEAROMATIZATION Domino reaction Alkynyl indole Synthetic method Cyclization

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Access to Polycyclic lndol(en)ines via Base-Catalyzed Intramolecular Dearomatizing 3-Alkenylation of Alkynyl Indoles

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