Degradation of lipid droplets by chimeric autophagy-tethering compounds

查看全文 作　　者：Yuhua [1]Fu;Ningxie [1]Chen;Ziying [1]Wang;Shouqing [2]Luo;Yu [1]Ding;Boxun [1]Lu

机构地区：[1]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Huashan Hospital,School of Life Sciences,Fudan University,Shanghai,China;[2]Peninsula Schools of Medicine and Dentistry,Institute of Translational and Stratified Medicine,University of Plymouth,Plymouth,UK

出　　处：《Cell Research》索引2021年第31卷第9期,共15页

基　　金：This study was supported by the National Natural Science Foundation of China(82050008,81925012,31970748,82030106);Science and Technology Commission of Shanghai Municipality(20JC1410900,18410722100);the Newton Advanced Fellowship(NAF\R1\191045),Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);ZJLab and Shanghai Center for Brain Science and Brain-Inspired Technology. 摘　　要：Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging. 关键词：COMPOUNDS PATHOGENIC challenging

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Degradation of lipid droplets by chimeric autophagy-tethering compounds

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