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Construction of heparin-based hydrogel incorporated with Cu_(5.4)O ultrasmall nanozymes for wound healing and inflammation inhibition

查看全文 作　　者：Yuan [1]Peng;Danfeng [2]He;Xin [3]Ge;Yifei [2]Lu;Yuanhao [4]Chai;Yixin [1]Zhang;Zhengwei [5]Mao;Gaoxing [2]Luo;Jun [2]Deng;Yan [1]Zhang 高影响力作者 机构地区：[1]Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,639 Zhi Zao Ju Road,Shanghai,200011,China;[2]Institute of Burn Research,Southwest Hospital,State Key Lab of Trauma,Burn and Combined Injury,Chongqing Key Laboratory for Disease Proteomics,Third Military Medical University(Army Medical University),Chongqing,400038,China;[3]Department of Gastroenterology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing,400010,China;[4]McKelvey School of Engineering,Washington University in Saint Louis,One Brookings Drive Saint Louis,MO,63130,USA;[5]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou,310027,China高影响力机构 出　　处：《Bioactive Materials》索引2021年第6卷第10期,共16页高影响力期刊 基　　金：This work was financially supported by National Natural Science Foundation of China(Grant No.51703243,81630055,81920108022);Project of Science and Technology Commission of Shanghai municipality(Grant No.18441904500,19441912300)。 摘　　要：Excessive production of inflammatory chemokines and reactive oxygen species(ROS)can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing.The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel‘weeding and uprooting’treatment strategy for inflammatory conditions.In the present study,a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol(starPEG)and heparin for chemokine sequestration as well as Cu_(5.4)O ultrasmall nanozymes for ROS scavenging(Cu_(5.4)O@Hep-PEG)was developed.The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8,decreasing the migratory activity of macrophages and neutrophils.Furthermore,it scavenges the ROS in wound fluids to mitigate oxidative stress,and the sustained release of Cu_(5.4)O promotes angiogenesis.In acute wounds and impaired-healing wounds(diabetic wounds),Cu_(5.4)O@Hep-PEG hydrogels outperform the standard-of-care product Promogram®in terms of inflammation reduction,increased epidermis regeneration,vascularization,and wound closure. 关 键 词：Inflammatory chemokines Reactive oxygen species Nanozymes HYDROGELS Wound healing
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