Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications

查看全文 作　　者：Maria Godoy-[1]Gallardo;Ulrich [2]Eckhard;Luis [1]M.Delgado;Yolanda J.D.de Roo [1]Puente;Mireia Hoyos-[1]Nogués;F.Javier [1]Gil;Roman [1]A.Perez

机构地区：[1]Bioengineering Institute of Technology,Universitat Internacional de Catalunya,Carrer de Josep Trueta,08195,del Vallès,Sant Cugat,Barcelona,Spain;[2]Proteolysis Lab,Department of Structural Biology,Molecular Biology Institute of Barcelona,CSIC,Barcelona Science Park,Baldiri Reixac 15-21,08028,Barcelona,Spain

出　　处：《Bioactive Materials》索引2021年第6卷第12期,共21页

基　　金：M.G-G and U.E have received funding from the postdoctoral fellowship programme Beatriu de Pinós,funded by the Secretary of Universities and Research(Government of Catalonia)and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie grant agreement No 801370;R.A.P is supported by the Spanish Ministry by the Ram´on y Cajal Program(RYC2018-025977-I);Additional financial support was provided by the Government of Catalonia(2017 SGR 708)and MINECO/FEDER project(RTI2018-096088-J-100). 摘　　要：Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. 关键词：Metal ions Metal nanoparticles Mechanism of action Antibacterial activity Tissue engineering Biomaterials applications

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Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications

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