Juvenile hormone receptor Met regulates sleep and neuronal morphology via glial-neuronal crosstalk

查看全文 作　　者：Binbin [1]Wu;Lei [1]He;Yutong [1]Xiao;Juan [1]Du;Xiaoxiao [2]Wang;Zhangwu [1]Zhao

机构地区：[1]Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management,College of Plant Protection,China Agricultural University,Beijing 100193,China;[2]College of Life Sciences,Hebei University,Baoding 071002,China

出　　处：《Journal of Genetics and Genomics》索引2021年第48卷第8期,共10页

基　　金：supported by the National Natural Science Foundation of China Grants 31970458 and 31730076(to Z.W.Zhao)。 摘　　要：Juvenile hormone(JH)is one of the most important hormones in insects since it is essential for insect development.The mechanism by which JH affects the central nervous system still remains a mystery.In this study,we demonstrate that one of the JH receptors,Methoprene-tolerant(Met),is important for the control of neurite development and sleep behavior in Drosophila.With the identification of Met-expressing glial cells,the mechanism that Met negatively controls the mushroom body(MB)b lobes fusion and positively maintains pigment-dispersing factor s LNvs projection pruning has been established.Furthermore,despite the developmental effects,Met can also maintain nighttime sleep in a developmentindependent manner through the a/b lobe of MB.Combining analyses of neuronal morphology and entomological behavior,this study advances our understanding of how the JH receptor regulates the nervous system. 关键词：MET SLEEP Glial cells DROSOPHILA Mushroom body PDF projection

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Juvenile hormone receptor Met regulates sleep and neuronal morphology via glial-neuronal crosstalk

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