Recent developments in the medicinal chemistry of single boron atom-containing compounds

查看全文 作　　者：Shu [1]Song;Ping [1]Gao;Lin [1]Sun;Dongwei [1]Kang;Jacob [2]Kongsted;Vasanthanathan [2]Poongavanam;Peng [1]Zhan;Xinyong [1]Liu

机构地区：[1]Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji'ncin 250012,China;[2]Department of Physics,Chemistry and Pharmacy,University of Southern Denmark,Odense M.DK-5230,Denmark

出　　处：《Acta Pharmaceutica Sinica B》索引2021年第11卷第10期,共25页

基　　金：Financial support from the National Natural Science Foundation of China(No.81973181,to Xinyong Liu,China);Shandong Provincial Key Research and Development Project(No.2019JZZY021011,to Peng Zhan,China);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(2019ZX09301126,to Xinyong Liu,China);Outstanding Youth Fund of Shandong Province(ZR2020JQ31,to Peng Zhan,China);Foreign Cultural and Educational Experts Project(GXL20200015001,to Xinyong Liu,China);the Program for Outstanding Ph.D.Candidate of Shandong University(to Lin Sun,China);Qilu Young Scholars Program of Shandong University(to Peng Zhan,China);the Taishan Scholar Program at Shandong Province(to Xinyong Liu,China)。 摘　　要：Various boron-containing drugs have been approved for clinical use over the past two decades,and more are currently in clinical trials.The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;for example,boron substitution can be used to modulate biological activity,pharmacokinetic properties,and drug resistance.In this perspective,we aim to comprehensively review the current status of boron compounds in drug discovery,focusing especially on progress from 2015 to December 2020.We classify these compounds into groups showing anticancer,antibacterial,antiviral,antiparasitic and other activities,and discuss the biological targets associated with each activity,as well as potential future developments. 关键词：Boron-containing compounds Covalent inhibitors PRODRUG Linker components

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Recent developments in the medicinal chemistry of single boron atom-containing compounds

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