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Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

查看全文 作　　者：Shuo [1,2]Du;Pulan [1,2]Liu;Zhiying [1,2]Zhang;Tianhe [2,3,4]Xiao;Ayijiang [2,3,4]Yasimayi;Weijin [5]Huang;Youchun [5]Wang;Yunlong [3,4]Cao;Xiaoliang Sunney [2,3,4,6]Xie;Junyu [1,2,3,6]Xiao 高影响力作者 机构地区：[1]State Key Laboratory of Protein and Plant Gene Research,Peking University,Beijing,China;[2]School of Life Sciences,Peking University,Beijing,China;[3]Beijing Advanced Innovation Center for Genomics(ICG),Peking University,Beijing,China;[4]Biomedical Pioneering Innovation Center(BIOPIC),Peking University,Beijing,China;[5]Division of HIV/AIDS and Sex-Transmitted Virus Vaccines,Institute for Biological Product Control,National Institutes for Food and Drug Control(NIFDC),Beijing,China;[6]Peking-Tsinghua Center for Life Sciences,Peking University,Beijing,China高影响力机构 出　　处：《Cell Research》索引2021年第31卷第10期,共4页高影响力期刊 基　　金：We thank the Core Facilities at the School of Life Sciences, Peking University for help with negative-staining EM;the Cryo-EM Platform of Peking University for help with data collection;the High-performance Computing Platform of Peking University for help with computation. We also thank Shuimu BioSciences Ltd. and Chuan Liu for the help with some data collection and processing. The work was supported by the National Key R&D Program of China (2020YFC0848700, 2017YFA0505200);the National Natural Science Foundation of China (31822014), and the Qidong-SLS Innovation Fund. 摘　　要：Dear Editor,The spread of the SARS-CoV-2 variants,especially the global variants of concern(VOCs),could seriously dampen our efforts to tackle the COVID-19 pandemic.The SARS-CoV-2 spike protein recognizes the host angiotensin-converting enzyme 2(ACE2)via its receptor-binding domain(RBD)to mediate viral entry into the cells.Several notorious mutations have been identified in the spike RBD of the VOCs.For example,B.1.1.7(Alpha),B.1.351(Beta),and P.1(Gamma)all contain the N501Y mutation,which increases the binding affinity for human ACE2 and confers higher infectivity in mice. 关 键 词：ACE2 concerning NEUTRAL
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