Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases

查看全文 作　　者：Winston Hernández-[1]Ceballos;Jacqueline Cordova-[2,3]Gallardo;Nahum Mendez-[3,4]Sanchez

机构地区：[1]Plan of Combined Studies in Medicine(PECEM-MD/PhD),Faculty of Medicine,National Autonomous University of Mexico,Mexico City,Mexico;[2]Department of Hepatology,Service of Surgery and Obesity Clinic,General Hospital“Dr.Manuel Gea González”,Mexico City,Mexico;[3]Faculty of Medicine.National Autonomous University of Mexico,Mexico City,Mexico;[4]Liver Research Unit,Medica Sur Clinic&Foundation,Mexico City,Mexico

出　　处：《Journal of Clinical and Translational Hepatology》索引2021年第9卷第2期,共12页

摘　　要：The gut microbiome plays a key role in the health-disease balance in the human body.Although its composition is unique for each person and tends to remain stable throughout lifetime,it has been shown that certain bacterial patterns may be determining factors in the onset of certain chronic metabolic diseases,such as type 2 diabetes mellitus(T2DM),obesity,metabolic-associated fatty liver disease(MAFLD),and metabolic syndrome.The gut-liver axis embodies the close relationship between the gut and the liver;disturbance of the normal gut microbiota,also known as dysbiosis,may lead to a cascade of mechanisms that modify the epithelial properties and facilitate bacterial translocation.Regulation of gut microbiota is fundamental to maintaining gut integrity,as well as the bile acids composition.In the present review,we summarize the current knowledge regarding the microbiota,bile acids composition and their association with MAFLD,obesity,T2DM and metabolic syndrome. 关键词：Metabolic-associated fatty liver disease Metabolic-associated steatohepatitis Gut microbiota Gut-liver axis DYSBIOSIS Bile acids

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Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases

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耦合文献(181)

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