Potential benefit of high-dose intravenous vitamin C for coronavirus disease 2019 pneumonia

查看全文 作　　者：Bing [1]Zhao;Mengjiao [1]Li;Yun [2]Ling;Yibing [3]Peng;Jun [4]Huang;Hongping [5]Qu;Yuan [6]Gao;Yingchuan [7]Li;Bijie [8]Hu;Shuihua [9]Lu;Hongzhou [2]Lu;Wenhong [10]Zhang;Enqiang [1]Mao 机构地区：[1]Department of Emergency,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[2]Department of Infectious Disease,Shanghai Public Health Clinical Center,Shanghai 201508,China;[3]Department of Laboratory Medicine,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;[4]Shanghai Institute of Hypertension,Shanghai 200025,China;[5]Department of Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[6]Department of Critical Care Medicine,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200217,China;[7]Department of Critical Care Medicine,The Sixth People's Hospital,Shanghai Jiao Tong University,Shanghai 200233,China;[8]Department of Infectious Disease,Zhongshan Hospital,Fudan University,Shanghai 200032,China;[9]Tuberculosis Department of Shanghai Public Health Clinical Center,Shanghai 201508,China;[10]Department of Infectious Disease of Shanghai Huashan Hospital,Fudan University,Shanghai 200040,China 出　　处：《Chinese Medical Journal》索引2022年第1期,共3页 基　　金：This study was supported by the grants from the second batch of the emergency key scientific and technological project of Shanghai Municipal Committee of Science and Technology(Nos.20411950300 and 20411950301)。 摘　　要：The coronavirus disease 2019(COVID-19)has been declared as a pandemic by the World Health Organization.[1]Most COVID-19 patients exhibit mild to moderate symptoms,while approximately 15%progress rapidly to severe pneumonia,and about 5%eventually develop acute respiratory distress syndrome(ARDS),[2]which requires mechanical ventilation(MV)and even extracorporeal membrane oxygenation.The mortality of COVID-19 patients who received MV was reported to be as high as 66%.[3]Therefore,the treatments aiming to improve mortality should focus on two aspects:first,prevention of the aggravation of the disease in mild and moderate COVID-19 patients;second,the rescue therapy for patients in serious conditions.We have been applying high-dose intravenous vitamin C(HDIVC)in the treatment of critical illnesses for almost 10 years in our center.Our previous in vivo research showed that HDIVC protected hemorrhagic shock-related multiple organ failure(MOF)by inhibiting inflammatory cytokines and oxidative indicators through activating Sirtuin1 pathway. 关 键 词：VITAMIN PNEUMONIA prevention