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Prognostic nomogram incorporating radiological features for predicting overall survival in patients with AIDS-related non-Hodgkin lymphoma

查看全文 作　　者：Xueqin [1]Li;Ziang [2]Pan;Xing [1]Wang;Tianli [3]Hu;Wen [4]Ye;Dongmei [5]Jiang;Wen [6]Shen;Jinxin [3]Liu;Yuxin [4]Shi;Shuang [6]Xia;Hongjun [1]Li 高影响力作者 机构地区：[1]Radiological Department,Beijing You'an Hospital Affiliated of Capital Medical University,Beijing 100069,China;[2]Neurological Department,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;[3]Radiological Department,The Eighth People's Hospital of Guangzhou,Guangzhou,Guangdong 510060,China;[4]Radiological Department,Shanghai Public Health Clinical Center,Affiliated of Fudan University,Shanghai 201058,China;[5]Radiation Department,Tianjin First Central Hospital,Tianjin 300170,China;[6]Radiological Department,Tianjin First Central Hospital,Tianjin 300192,China高影响力机构 出　　处：《Chinese Medical Journal》索引2022年第1期,共9页高影响力期刊 摘　　要：Background: Acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (AR-NHL) is a high-risk factor for morbidity and mortality in patients with AIDS. This study aimed to determine the prognostic factors associated with overall survival (OS) and to develop a prognostic nomogram incorporating computed tomography imaging features in patients with acquired immune deficiency syndrome-related non-Hodgkin lymphoma (AR-NHL).Methods: A total of 121 AR-NHL patients between July 2012 and November 2019 were retrospectively reviewed. Clinical and radiological independent predictors of OS were confirmed using multivariable Cox analysis. A prognostic nomogram was constructed based on the above clinical and radiological factors and then provided optimum accuracy in predicting OS. The predictive accuracy of the nomogram was determined by Harrell C-statistic. Kaplan-Meier survival analysis was used to determine median OS. The prognostic value of adjuvant therapy was evaluated in different subgroups.Results: In the multivariate Cox regression analysis, involvement of mediastinal or hilar lymph nodes, liver, necrosis in the lesions, the treatment with chemotherapy, and the CD4 ≤100 cells/μL were independent risk factors for poor OS (allP < 0.050). The predictive nomogram based on Cox regression has good discrimination (Harrell C-index = 0.716) and good calibration (Hosmer-Lemeshow test,P = 0.620) in high- and low-risk groups. Only patients in the high-risk group who received adjuvant chemotherapy had a significantly better survival outcome.Conclusion: A survival-predicting nomogram was developed in this study, which was effective in assessing the survival outcomes of patients with AR-NHL. Notably, decision-making of chemotherapy regimens and more frequent follow-up should be considered in the high-risk group determined by this model. 关 键 词：LYMPHOMA AIDS-related AR-NHL Computed tomography Prognosis NOMOGRAM
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