Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19

查看全文 作　　者：LI Ling [1]Hua;TU Hong [2]Wei;LIANG [2]Dan;WEN Chun [1]Yan;LI An [3]An;LIN Wei [1]Yin;HU Ke [3]Qi;HONG Wen [4]Shan;LI Yue [1]Ping;SU [2]Juan;ZHAO San [1]Tao;LI [2]Wei;YUAN Run [2]Yu;ZHOU Ping [2]Ping;HU Feng [1]Yu;TANG Xiao [1]Ping;KE Chang [2]Wen;KE Bi [2]Xia;CAI Wei [1]Ping

机构地区：[1]Guangzhou Eighth People’s Hospital,Guangzhou Medical University,Guangzhou 510060,Guangdong,China;[2]Guangdong Provincial Center for Diseases Control and Prevention,Guangzhou 511430,Guangdong,China;[3]School of Public Health,Southern Medical University,Guangzhou 510515,Guangdong,China;[4]Shantou University Medical College,Shantou 515063,Guangdong,China

出　　处：《Biomedical and Environmental Sciences》索引2021年第34卷第12期,共8页

基　　金：the Guangdong Provincial Novel Coronavirus Scientific and Technological Project[2020111107001 and202008040004];the National Key Research and Development Program of China[2020YFC0846900];the Guangzhou Basic Research Program on People’s Livelihood Science and Technology[202002020005];the National Natural Science Foundation of China[82003487 and 82072265]。 摘　　要：Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. 关键词：SEX KINETICS Neutralizing antibody SARS-CoV-2

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Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19

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