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Role of chemokines in the hepatocellular carcinoma microenvironment and their translational value in immunotherapy

查看全文 作　　者：Yijun [1]Wang;Mengyu [1]Sun;Tongyue [1]Zhang;Yangyang [1]Feng;Xiangyuan [1]Luo;Meng [1]Xie;Xiaoyu [1]Ji;Danfei [1]Liu;Wenjie [2]Huang;Limin [1]Xia 高影响力作者 机构地区：[1]Department of Gastroenterology,Institute of Liver and Gastrointestinal Diseases,Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;[2]Hepatic Surgery Center,Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China高影响力机构 出　　处：《Oncology and Translational Medicine》索引2022年第8卷第1期,共17页高影响力期刊 基　　金：Supported by grants from the National Natural Science Foundation of China(No.81871911[W.H.],No.81772623[L.X.],and No.81972237[L.X.]);the National Key Research and Development Program of China(No.2018YFC1312103[L.X.]). 摘　　要：The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven tumor.Chronic inflammation allows nascent tumors to escape immunosurveillance.Chemokines are small,soluble,secreted proteins that can regulate the activation and trafficking of immune cells during inflammation.Several studies have shown that various chemokines with overarching functions disrupt the immune microenvironment during the initiation and progression of HCC.The dysregulated chemokine network in HCC contributes to multiple malignant processes,including angiogenesis,tumor proliferation,migration,invasion,tumor low response,and resistance to immune therapy.Here,we summarize the current studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,highlighting potential translational therapeutic uses for modulating the chemokine system in HCC. 关 键 词：hepatocellular carcinoma CHEMOKINE chemokine receptor tumor microenvironment immune therapy therapeutic target
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