Real-Time High-Resolution MRI Endoscopy at up to 10 Frames per Second

查看全文 作　　者：Xiaoyang [1,2]Liu;Parag [2]Karmarkar;Dirk [3]Voit;Jens [3]Frahm;Clifford [4]R.Weiss;Dara [2]L.Kraitchman;Paul [1,2]A.Bottomley

机构地区：[1]Department of Electrical and Computer Engineering,Johns Hopkins University,USA;[2]The Division of MR Research,Department of Radiology,Johns Hopkins University,Baltimore,Maryland,USA;[3]Biomedizinishe NMR,Max-Plank-Institut fur Biophysikalische Chemie,Gottingen,Germany;[4]The Division of Interventional Radiology,Department of Radiology,Johns Hopkins University,Baltimore,Maryland,USA

出　　处：《Biomedical Engineering Frontiers》索引2021年第2卷第1期,共10页

基　　金：supported by grants R01 EB007829 from the National Institutes of Health,Siemens Medical Systems;Russell H Morgan Professorship in Radiology。 摘　　要：Objective.Atherosclerosis is a leading cause of mortality and morbidity.Optical endoscopy,ultrasound,and X-ray offer minimally invasive imaging assessments but have limited sensitivity for characterizing disease and therapeutic response.Magnetic resonance imaging(MRI)endoscopy is a newer idea employing tiny catheter-mounted detectors connected to the MRI scanner.It can see through vessel walls and provide soft-tissue sensitivity,but its slow imaging speed limits practical applications.Our goal is highresolution MRI endoscopy with real-time imaging speeds comparable to existing modalities.Methods.Intravascular(3 mm)transmit-receive MRI endoscopes were fabricated for highly undersampled radial-projection MRI in a clinical 3-tesla MRI scanner.Iterative nonlinear reconstruction was accelerated using graphics processor units connected via a single ethernet cable to achieve true real-time endoscopy visualization at the scanner.MRI endoscopy was performed at 6-10 frames/sec and 200-300μm resolution in human arterial specimens and porcine vessels ex vivo and in vivo and compared with fully sampled 0.3 frames/sec and three-dimensional reference scans using mutual information(MI)and structural similarity(3-SSIM)indices.Results.High-speed MRI endoscopy at 6-10 frames/sec was consistent with fully sampled MRI endoscopy and histology,with feasibility demonstrated in vivo in a large animal model.A 20-30-fold speed-up vs.0.3 frames/sec reference scans came at a cost of~7%in MI and~45%in 3-SSIM,with reduced motion sensitivity.Conclusion.High-resolution MRI endoscopy can now be performed at frame rates comparable to those of X-ray and optical endoscopy and could provide an alternative to existing modalities,with MRI’s advantages of soft-tissue sensitivity and lack of ionizing radiation. 关键词：SCANNER FRAMES mounted

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Real-Time High-Resolution MRI Endoscopy at up to 10 Frames per Second

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