Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

查看全文 作　　者：Liang [1]Wang;Olwen [2]Murphy;Natalia Gonzalez [2]Caldito;Peter [2]A.Calabresi;Shiv [2]Saidha

机构地区：[1]Department of Biology,Johns Hopkins University,Krieger School of Arts and Sciences,Baltimore,MD,USA;[2]Division of Neuroimmunology and Neurological Infections,Johns Hopkins Hospital,600 N.Wolfe St.,Baltimore,MD 21287,USA

出　　处：《Eye and Vision》索引2018年第5卷第1期,共11页

基　　金：supported in part by a grant(RG-1606-08768)from the National Multiple Sclerosis Society to SS. 摘　　要：Purpose:To review the clinical and research value of optical coherence tomography angiography(OCTA)in the field of neurology.Methods:Current literature involving OCTA were reviewed through PubMed using the search terms“optical coherence tomography angiography”,with“multiple sclerosis”,“Alzheimer’s disease”,“optic neuropathy”,or other closely-related terms.Results:OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders.OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis(MS),Alzheimer’s disease(AD),and various optic neuropathies(ON)in varying regions of the posterior segment vasculature of the eye.These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders.Conclusion:OCTA may be beneficial for neurological research.Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders. 关键词：Optical coherence tomography angiography NEUROLOGY Multiple sclerosis Alzheimer’s disease Optic neuropathy

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Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

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