N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes for in vivo cell H_(2)S imaging

查看全文 作　　者：Yan [1,2]Shi;Fangjun [3]Huo;Yongkang [1]Yue;Caixia [1]Yin

机构地区：[1]Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan 030006,China;[2]College of Food Sciences,Shanxi Normal University,Linfen 041004,China;[3]Research Institute of Applied Chemistry,Shanxi University,Taiyuan 030006,China

出　　处：《Frontiers of Chemical Science and Engineering》索引2022年第16卷第1期,共8页

基　　金：the National Natural Science Foundation of China(Grant Nos.21775096 and 21878180);One hundred people plan of Shanxi Province,Shanxi Province“1331 project”key innovation team construction plan cultivation team(No.2018-CT-1);2018 Xiangyuan County Solid Waste Comprehensive Utilization Science and Technology Project(No.2018XYSDJS-05);Key R&D Program of Shanxi Province(No.201903D421069);the Shanxi Province Science Foundation(No.201901D111015);Shanxi Collaborative Innovation Center of High Valueadded Utilization of Coal-related Wastes(No.2015-10-B3);the Shanxi Province Foundation for Selected Returnee(No.2019),Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0031);Project of Graduate Innovation of Shanxi Province(No.2020);Key R&D and transformation plan of Qinghai Province(No.2020-GX-101);Scientific Instrument Center of Shanxi University(No.201512). 摘　　要：Heterocyclic compound quinoline and its derivatives exist in natural compounds and have a broad spectrum of biological activity.They play an important role in the design of new structural entities for medical applications.Similarly,indoles and their derivatives are found widely in nature.Amino acids,alkaloids and auxin are all derivatives of indoles,as are dyes,and their condensation with aldehydes makes it easy to construct reaction sites for nucleophilic addition agents.In this work,we combine these two groups organically to construct a rapid response site(within 30 s)for H_(2)S,and at the same time,a ratiometric fluorescence response is presented throughout the process of H_(2)S detection.As such,the lower detection limit can reach 55.7 nmol/L for H_(2)S.In addition,cell imaging shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous H_(2)S.Finally,this probe application was verified by imaging H_(2)S in nude mice. 关键词：heterocyclic compound hydrogen sulfide RATIOMETRIC mitochondrial targeted

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N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes for in vivo cell H_(2)S imaging

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