The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

查看全文 作　　者：Kaifan [1,2]Zhang;Yan [1]Wang;Tianda [2]Fan;Cheng [1,3]Zeng;Zhong Sheng [1,2,3,4]Sun

机构地区：[1]Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China;[2]Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou 325000,China;[3]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing 100049,China;[4]State Key Laboratory of Integrated Management of Pest Insects and Rodents,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Protein & Cell》索引2022年第13卷第1期,共20页

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.32070590 and 31871191);the Guangdong Key Project in the“development of new tools for diagnosis and treatment of Autism”(2018B030335001). 摘　　要：The serine/threonine p21-activated kinases(PAKs),as main effectors of the Rho GTPases Cdc42 and Rac,represent a group of important molecular switches linking the complex cytoskeletal networks to broad neural activity.PAKs show wide expression in the brain,but they differ in specific cell types,brain regions,and developmental stages.PAKs play an essential and differential role in controlling neural cytoskeletal remodeling and are related to the development and fate of neurons as well as the structural and functional plasticity of dendritic spines.PAK-mediated actin signaling and interacting functional networks represent a common pathway frequently affected in multiple neurodevelopmental and neurodegenerative disorders.Considering specific small-molecule agonists and inhibitors for PAKs have been developed in cancer treatment,comprehensive knowledge about the role of PAKs in neural cytoskeletal remodeling will promote our understanding of the complex mechanisms underlying neurological diseases,which may also represent potential therapeutic targets of these diseases. 关键词：p21-activated kinases expression pattern synaptic cytoskeletal remodeling neuronal function neurological diseases

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The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

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