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Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis

查看全文 作　　者：Mary M [1]Barker;Francesco [1]Zaccardi;Emer M [1]Brady;Gaurav S [2]Gulsin;Andrew P [3]Hall;Joseph [4]Henson;Zin [1]ZinHtike;Kamlesh [5,6]Khunti;Gerald P [2,4]McCann;Emma L [4,5,6]Redman;David R [4]Webb;Emma G [7]Wilmot;Tom [4]Yates;Jian [2]Yeo;Melanie J [4,6]Davies;Jack A [1]Sargeant 高影响力作者 机构地区：[1]Diabetes Research Centre,University of Leicester,Leicester General Hospital,Leicester LE54PW,United Kingdom;[2]Department of Cardiovascular Sciences,Glenfield Hospital,University of Leicester,Leicester LE39QP,United Kingdom;[3]The Hanning Sleep Laboratory,University Hospitals of Leicester NHS Trust,University of Leicester,Leicester LE54PW,United Kingdom;[4]National Institute for Health Research,Leicester Biomedical Research Centre,Leicester LE54PW,United Kingdom;[5]Leicester Diabetes Centre,University Hospitals of Leicester NHS Trust,Leicester LE54PW,United Kingdom;[6]National Institute for Health Research,Applied Research Collaboration East Midlands,Leicester LE54PW,United Kingdom;[7]Department of Diabetes,University Hospitals of Derby and Burton NHS Foundation Trust,Derby DE223NE,United Kingdom高影响力机构 出　　处：《World Journal of Diabetes》索引2022年第13卷第3期,共12页高影响力期刊 基　　金：Supported by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (NIHR201165);by the NIHR Leicester Biomedical Research Centre;the NIHR Applied Research Collaboration East Midlands 摘　　要：BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. 关 键 词：Type 2 diabetes mellitus Early-onset adult type 2 diabetes Age of onset Cardiovascular risk Young adults Glycaemic control OBESITY
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